Reaction: D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3
For diagram click here.
Other name(s): glucosaminephosphate isomerase; glucosamine-6-phosphate isomerase; phosphoglucosaminisomerase; glucosamine phosphate deaminase; aminodeoxyglucosephosphate isomerase; phosphoglucosamine isomerase
Systematic name: 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
Comments: Formerly EC 184.108.40.206. Isomerization of the aldose-ketose type converts the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia. N-Acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9013-10-9
1. Comb, D.G., Roseman, S. Glucosamine metabolism. IV. Glucosamine-6-phosphate deaminase. J. Biol. Chem. 232 (1958) 807-827
2. Pattabiraman, T.N., Bachhawat, B.K. Purification of glucosamine 6-phosphate deaminase from human brain. Biochim. Biophys. Acta 54 (1961) 273-283.
3. Wolfe, J.B., Britton, B.B., Nakada, H.I. Glucosamine degradation by Escherichia coli. III. Isolation and studies of "phosphoglucosaminisomerase". Arch. Biochem Biophys. 66 (1957) 333-339