IUBMB Enzyme Nomenclature

EC 3.5.99.6

Accepted name: glucosamine-6-phosphate deaminase

Reaction: α-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3

For diagram click here.

Glossary: α-D-glucosamine 6-phosphate = 2-amino-2-deoxy-α-D-glucopyranose 6-phosphate

Other name(s): glucosaminephosphate isomerase; glucosamine-6-phosphate isomerase; phosphoglucosaminisomerase; glucosamine phosphate deaminase; aminodeoxyglucosephosphate isomerase; phosphoglucosamine isomerase; 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)

Systematic name: 2-amino-2-deoxy-α-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)

Comments: The enzyme uses ring opening and isomerization of the aldose-ketose type to convert the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia. N-Acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9013-10-9

References:

1. Wolfe, J.B., Britton, B.B., Nakada, H.I. Glucosamine degradation by Escherichia coli. III. Isolation and studies of "phosphoglucosaminisomerase". Arch. Biochem. Biophys. 66 (1957) 333-339. [PMID: 13403679]

2. Comb, D.G., Roseman, S. Glucosamine metabolism. IV. Glucosamine-6-phosphate deaminase. J. Biol. Chem. 232 (1958) 807-827. [PMID: 13549465]

3. Pattabiraman, T.N., Bachhawat, B.K. Purification of glucosamine 6-phosphate deaminase from human brain. Biochim. Biophys. Acta 54 (1961) 273-283. [PMID: 14484386]

4. Liu, C., Li, D., Liang, Y.H., Li, L.F. and Su, X.D. Ring-opening mechanism revealed by crystal structures of NagB and its ES intermediate complex. J. Mol. Biol. 379 (2008) 73-81. [PMID: 18436239]

[EC 3.5.99.6 created 1961 as EC 5.3.1.10, transferred 2000 to EC 3.5.99.6]


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