IUBMB Enzyme Nomenclature


Accepted name: FAD diphosphatase

Reaction: FAD + H2O = AMP + FMN

For diagram of reaction click here.

Other name(s): FAD pyrophosphatase; riboflavin adenine dinucleotide pyrophosphatase; flavin adenine dinucleotide pyrophosphatase; riboflavine adenine dinucleotide pyrophosphatase; flavine adenine dinucleotide pyrophosphatase

Systematic name: FAD nucleotidohydrolase

Comments: The plant enzyme also hydrolyses NAD+ and NADH; the animal enzyme hydrolyses NAD+ and CoA at about half of the rate of hydrolysis of FAD. May be identical with EC nucleotide diphosphatase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37289-30-8


1. Ravindranath, S.D. and Appaji Rao, N. Nucleotidases in plants. 3. Effect of metabolites on the enzyme hydrolyzing flavine adenine dinucleotide (FAD) from Phaseolus radiatus. Arch. Biochem. Biophys. 133 (1969) 54-59. [PMID: 5810832]

2. Shin, H.J. and Mego, J.L. A rat liver lysosomal membrane flavin-adenine dinucleotide phosphohydrolase: purification and characterization. Arch. Biochem. Biophys. 267 (1988) 95-103. [PMID: 2848456]

[EC created 1972]

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