Reaction: 1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate
For diagram click here.
Other name(s): phosphoribosyl-ATP pyrophosphatase; phosphoribosyladenosine triphosphate pyrophosphatase
Systematic name: 1-(5-phosphoribosyl)-ATP diphosphohydrolase
Comments: The Neurospora crassa enzyme also catalyses the reactions of EC 1.1.1.23 (histidinol dehydrogenase) and EC 3.5.4.19 (phosphoribosyl-AMP cyclohydrolase).
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 69553-55-5
References:
1. Smith, D.W.E. and Ames, B.N. Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis.J. Biol. Chem. 240 (1965) 3056-3063.