Reaction: ATP + 2 H2O = AMP + 2 phosphate
Other name(s): ATP-diphosphatase; adenosine diphosphatase; ADPase; ATP diphosphohydrolase [ambiguous]
Systematic name: ATP diphosphohydrolase (phosphate-forming)
Comments: Requires Ca2+. Also acts on ADP, and on other nucleoside triphosphates and diphosphates. Most of the ecto-ATPases occurring on the cell surface and hydrolysing extracellular nucleoside triphosphates and diphosphates belong to this enzyme family. Either Ca2+ or Mg2+ can serve as activating ions.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9000-95-7
1. Krishman, P.S. Apyrase, pyrophosphatase and metaphosphatase of Penicillium chrysogenum. Arch. Biochem. Biophys. 37 (1952) 224-234.
2. Liébecq, C., Lallemand, A. and Degueldre-Guillaume, M.-J. [Partial purification and properties of potato apyrase.] Bull. Soc. Chim. Biol. 45 (1963) 573-594.