IUBMB Enzyme Nomenclature

EC 3.6.1.64

Accepted name: inosine diphosphate phosphatase

Reaction: (1) IDP + H2O = IMP + phosphate
(2) dIDP + H2O = dIMP + phosphate

Other name(s): (deoxy)inosine diphosphatase; NUDT16

Systematic name: inosine diphosphate phosphatase

Comments: The human enzyme also hydrolyses GDP and dGDP, and to a lesser extent ITP, dITP and XTP.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Iyama, T., Abolhassani, N., Tsuchimoto, D., Nonaka, M. and Nakabeppu, Y. NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest. Nucleic Acids Res. 38 (2010) 4834-4843. [PMID: 20385596]

[EC 3.6.1.64 created 2013]


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