IUBMB Enzyme Nomenclature


Accepted name: nucleotide diphosphatase

Reaction: A dinucleotide + H2O = 2 mononucleotides

Other name(s): nucleotide pyrophosphatase; nucleotide-sugar pyrophosphatase

Systematic name: dinucleotide nucleotidohydrolase

Comments: Substrates include NAD+, NADP+, FAD, CoA and also ATP and ADP.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9032-64-8


1. Jacobson, J.B. and Kaplan, N.O. A reduced pyridine nucleotide pyrophosphatase. J. Biol. Chem. 226 (1957) 427-437.

2. Kornberg, A. and Pricer, W.E. Nucleotide pyrophosphatase. J. Biol. Chem. 182 (1950) 763-778.

3. Kumar, S.A., Rao, N.A. and Vaidyanathan, C.S. Nucleotidases in plants. I. Partial purification and properties of the enzyme hydrolyzing flavine adenine dinucleotide from mung bean seedlings (Phaseolus radiatus). Arch. Biochem. Biophys. 111 (1965) 646-652. [PMID: 5862212]

4. Swartz, M.N., Kaplan, N.O. and Lamborg, M.F. A "heat-activated" diphosphopyridine nucleotide pyrophosphatase from Proteus vulgaris. J. Biol. Chem. 232 (1958) 1051-1063.

[EC created 1961]

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