IUBMB Enzyme Nomenclature

EC 3.6.4.1

Accepted name: myosin ATPase

Reaction: ATP + H2O = ADP + phosphate

Other name: actomyosin

Systematic name: ATP phosphohydrolase (actin-translocating)

Comments: Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15-27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Rayment, I. The structural basis of myosin ATPase activity. J. Biol. Chem. 271 (1996) 15850-15853. [PMID: 8663496]

2. Hasson, T. and Mooseker, M.S. Vertebrate unconventional myosins. J. Biol. Chem. 271 (1996) 16431-16434. [PMID: 8690736]

3. Murphy, C.T. and Spudich, J.A. The sequence of the myosin 50-20K loop affects myosin's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity. Biochemistry 38 (1999) 3785-3792. [PMID: 10090768]

[EC 3.6.4.1 created 1984 as EC 3.6.1.32, transferred 2000 to EC 3.6.4.1]


Return to EC 3.6.4 home page
Return to EC 3.6 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page