Reaction: ATP + H2O = ADP + phosphate
Systematic name: kinesin ATP phosphohydrolase (minus-end-directed)
Comments: Structurally almost identical to EC 3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
References:
1. Henningsen, U. and Schliwa, M. Reversal in the direction of movement of a molecular motor. Nature 389 (1997) 93-96. [PMID: 9288974]
2. Sharp, D.J., Kuriyama, R., Essner, R. and Baas, P.W. Expression of a minus-end-directed motor protein induces Sh9 cells to form axon-like processes with uniform microtubule polarity orientation. J. Cell Sci. 110 (1997) 2373-2380. [PMID: 9410876]
3. Sablin, E.P., CASe, R.B., Dai, S.C., Hart, C.L., Ruby, A., Vale, R.D. and Fletterick, R.J. Direction determination in the minus-end-directed kinesin motor ncd. Nature 395 (1998) 813-816. [PMID: 9796817]