IUBMB Enzyme Nomenclature

EC 3.6.4.8

Accepted name: proteasome ATPase

Reaction: ATP + H2O = ADP + phosphate

Other name: RP triple-A protein; RP triphosphatase

Systematic name: ATP phosphohydrolase (polypeptide-degrading)

Comments: Belongs to the AAA-type superfamily and, like EC 3.6.4.5 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Rivett, A.J., Mason, G.G., Murray, R.Z. and Reidlinger, J. Regulation of proteasome structure and function. Mol. Biol. Rep. 24 (1997) 99-102. [PMID: 9228289]

2. Mason, G.G., Murray, R.Z., Pappin, D. and Rivett, A.J. Phosphorylation of ATPase subunits of the 26S proteasome. FEBS Lett. 430 (1998) 269-274. [PMID: 9688553]

[EC 3.6.4.8 created 2000]


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