Reaction: GTP + H2O = GDP + phosphate
Systematic name: GTP phosphohydrolase (vesicle-releasing)
Comments: An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:
1. Warnock, D.E. and Schmid, S.L. Dynamin GTPase, a force-generating molecular switch. Bioessays 18 (1996) 885-893. [PMID: 8939066]
2. McClure, S.J. and Robinson, P.J. Dynamin, endocytosis and intracellular signalling. Mol. Membr. Biol. 13 (1996) 189-215. [PMID: 9116759]
3. Oh, P., McIntosh, D.P. and Schnitzer, J.E. Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium. J. Cell Biol. 141 (1998) 101-114. [PMID: 9531551]