IUBMB Enzyme Nomenclature

EC 3.7.1.2

Accepted name: fumarylacetoacetase

Reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

Other name(s): β-diketonase; fumarylacetoacetate hydrolase

Systematic name: 4-fumarylacetoacetate fumarylhydrolase

Comments: Also acts on other 3,5- and 2,4-dioxo acids.

Links to other databases: BRENDA, EXPASY, KEGG, UM-BBD, Metacyc, PDB, UM-BBD, CAS registry number: 9032-59-1

References:

1. Connors, W.M. and Stotz, E. The purification and properties of a triacetic acid-hydrolyzing enzyme. J. Biol. Chem. 178 (1949) 881-890.

2. Edwards, S.W. and Knox, W.E. Homogentisate metabolism: the isomerization of maleylacetoacetate by an enzyme which requires glutathione. J. Biol. Chem. 220 (1956) 79-91.

3. Meister, A. and Greenstein, J.P. Enzymatic hydrolysis of 2,4-diketo acids. J. Biol. Chem. 175 (1948) 573-588.

[EC 3.7.1.2 created 1961]


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