IUBMB Enzyme Nomenclature


Accepted name: histidine decarboxylase

Reaction: L-histidine = histamine + CO2

Other name(s): L-histidine decarboxylase; L-histidine carboxy-lyase

Systematic name: L-histidine carboxy-lyase (histamine-forming)

Comments: A pyridoxal-phosphate protein (in animal tissues). The bacterial enzyme has a pyruvoyl residue as prosthetic group.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9024-61-7


1. Epps, H.M.R. Studies on bacterial amino-acid decarboxylases. 4. l(–)-Histidine decarboxylase from Cl. welchii type A. Biochem. J. 39 (1945) 42-46.

2. Riley, W.O. and Snell, E.E. Histidine decarboxylase of Lactobacillus 30a. IV. The presence of covalently bound pyruvate as the prosthetic group. Biochemistry 7 (1968) 3520-3528. [PMID: 5681461]

3. Rosenthaler, J., Guirard, B.M., Chang, G.W. and Snell, E.E. Purification and properties of histidine decarboxylase from Lactobacillus 30a. Proc. Natl. Acad. Sci. USA 54 (1965) 152-158. [PMID: 5216347]

[EC created 1961]

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