IUBMB Enzyme Nomenclature


Accepted name: 2,2-dialkylglycine decarboxylase (pyruvate)

Reaction: 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine

Other name(s): dialkyl amino acid (pyruvate) decarboxylase; α-dialkyl amino acid transaminase; 2,2-dialkyl-2-amino acid-pyruvate aminotransferase; L-alanine-α-ketobutyrate aminotransferase; dialkylamino-acid decarboxylase (pyruvate); 2,2-dialkylglycine carboxy-lyase (amino-transferring)

Systematic name: 2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)

Comments: A pyridoxal-phosphate protein. Acts on 2-amino-2-methylpropanoate (i.e. 2-methylalanine), 2-amino-2-methylbutanoate and 1-aminocyclopentanecarboxylate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9032-17-1


1. Bailey, G.B. and Dempsey, W.B. Purification and properties of an α-dialkyl amino acid transaminase. Biochemistry 6 (1967) 1526-1533.

[EC created 1972]

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