Reaction: 2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde
For diagram of reaction click here.
Other name(s): Pto1279 (gene name); KDGA; KDG-specific aldolase
Systematic name: 2-dehydro-3-deoxy-D-gluconate D-glyceraldehyde-lyase (pyruvate-forming)
Comments: The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. In the direction of aldol synthesis the enzyme catalyses the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate at a similar ratio. It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. cf. EC 188.8.131.52, 2-dehydro-3-deoxy-phosphogluconate aldolase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Reher, M., Fuhrer, T., Bott, M. and Schonheit, P. The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase. J. Bacteriol. 192 (2010) 964-974. [PMID: 20023024]