Reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate
For diagram of reaction click here
Other name(s): pyruvate aldolase; γ-methyl-γ-hydroxy-α-ketoglutaric aldolase; 4-hydroxy-4-methyl-2-ketoglutarate aldolase; 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase
Systematic name: 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)
Comments: Also acts on 4-hydroxy-4-methyl-2-oxoadipate and 4-carboxy-4-hydroxy-2-oxohexadioate.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 37290-65-6
References:
1. Maruyama, K. Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase. J. Biochem. (Tokyo) 93 (1983) 557-565. [PMID: 6841353]
2. Sharma, M.L., Kaul, S.M. and Shukla, O.P. Metabolism of 2-hydroxypyridine by Bacillus brevis (INA). Biol. Membr. 9 (1984) 43-52.
3. Tack, B.F., Chapman, P.J. and Dagley, S. Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase. J. Biol. Chem. 247 (1972) 6444-6449. [PMID: 5076765]
4. Wood, W.A. 2-Keto-3-deoxy-6-phosphogluconic and related aldolases, in Boyer, P.D. (Ed.), The Enzymes, 3rd edn., vol. 7, Academic Press, New York, 1972, pp. 281-302.