IUBMB Enzyme Nomenclature


Accepted name: citramalate lyase

Reaction: (2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate

For diagram click here.

Glossary: (+)-citramalate = (2S)-2-hydroxy-2-methylbutanedioate

Other name(s): citramalate pyruvate-lyase; citramalate synthase; citramalic-condensing enzyme; citramalate synthetase; citramalic synthase; (S)-citramalate lyase; (+)-citramalate pyruvate-lyase; citramalate pyruvate lyase; (3S)-citramalate pyruvate-lyase; (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase

Systematic name: (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase (acetate-forming)

Comments: The enzyme can be dissociated into components, two of which are identical with EC (citramalate CoA-transferase) and EC (citramalyl-CoA lyase).

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9027-93-4


1. Barker, H.A. Citramalate lyase of Clostridium tetanomorphum. Arch. Mikrobiol. 59 (1967) 4-12. [PMID: 4301387]

2. Dimroth, P., Buckel, W., Loyal, R. and Eggerer, H. Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase. Eur. J. Biochem. 80 (1977) 469-477. [PMID: 923590]

[EC created 1972]

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