Reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
For diagram of reaction click here.
Other name(s): anthranilate synthetase; chorismate lyase; chorismate pyruvate-lyase (amino-accepting); TrpE
Systematic name: chorismate pyruvate-lyase (amino-accepting; anthranilate-forming)
Comments: In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 188.8.131.52 (anthranilate phosphoribosyltransferase ), EC 184.108.40.206 (indole-3-glycerol-phosphate synthase), EC 220.127.116.11 (tryptophan synthase) and EC 18.104.22.168 (phosphoribosylanthranilate isomerase)]. The native enzyme in the complex uses either glutamine or, less efficiently, NH3. The enzyme separated from the complex uses NH3 only.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9031-59-8
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