IUBMB Enzyme Nomenclature


Accepted name: chorismate lyase

Reaction: chorismate = 4-hydroxybenzoate + pyruvate

For diagram of reaction click here.

Other name(s): CL; CPL; UbiC

Systematic name: chorismate pyruvate-lyase (4-hydroxybenzoate-forming)

Comments: This enzyme catalyses the first step in the biosynthesis of ubiquinone in Escherichia coli and other Gram-negative bacteria [1]. The yeast Saccharomyces cerevisiae can synthesize ubiquinone from either chorismate or tyrosine [3].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Nichols, B.P. and Green, J.M. Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase. J. Bacteriol. 174 (1992) 5309-5316. [PMID: 1644758]

2. Siebert, M., Severin, K. and Heide, L. Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase. Microbiology 140 (1994) 897-904. [PMID: 8012607]

3. Meganathan, R. Ubiquinone biosynthesis in microorganisms. FEMS Microbiol. Lett. 203 (2001) 131-139. [PMID: 11583838]

[EC created 2007]

Return to EC 4.1.3 home page
Return to EC 4.3 home page
Return to EC 4 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page