Reaction: L-tryptophan + H2O = indole + pyruvate + NH3
Other name(s): L-tryptophanase; L-tryptophan indole-lyase (deaminating)
Systematic name: L-tryptophan indole-lyase (deaminating; pyruvate-forming)
Comments: A pyridoxal-phosphate protein, requiring K+. Also catalyses 2,3-elimination and β-replacement reactions of some indole-substituted tryptophan analogues of L-cysteine, L-serine and other 3-substituted amino acids.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, PDB, CAS registry number: 9024-00-4
References:
1. Burns, R.O. and DeMoss, R.D. Properties of tryptophanase from Escherichia coli. Biochim. Biophys. Acta 65 (1962) 233-244. [PMID: 14017164]
2. Cowell, J.L., Maser, K. and DeMoss, R.D. Tryptophanase from Aeromonas liquifaciens. Purification, molecular weight and some chemical, catalytic and immunological properties. Biochim. Biophys. Acta 315 (1973) 449-463.
3. Newton, W.A., Morino, Y. and Snell, E.E. Properties of crystalline tryptophanase. J. Biol. Chem. 240 (1965) 1211-1218. [PMID: 14284727]