Reaction: L-tyrosine + H2O = phenol + pyruvate + NH3
Other name(s): β-tyrosinase; L-tyrosine phenol-lyase (deaminating)
Systematic name: L-tyrosine phenol-lyase (deaminating; pyruvate-forming)
Comments: A pyridoxal-phosphate protein. The enzyme also slowly catalyses pyruvate formation from D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9059-31-8
1. Kumagai, H., Yamada, H., Matsui, H., Ohkishi, H. and Ogata, K. Tyrosine phenol lyase. I. Purification, crystallization, and properties. J. Biol. Chem. 245 (1970) 1767-1772. [PMID: 4908868]
2. Kumagai, H., Yamada, H., Matsui, H., Ohkishi, H. and Ogata, K. Tyrosine phenol lyase. II. Cofactor requirements. J. Biol. Chem. 245 (1970) 1773-1777. [PMID: 4908869]