IUBMB Enzyme Nomenclature

EC 4.1.99.2

Accepted name: tyrosine phenol-lyase

Reaction: L-tyrosine + H2O = phenol + pyruvate + NH3

Other name(s): β-tyrosinase; L-tyrosine phenol-lyase (deaminating)

Systematic name: L-tyrosine phenol-lyase (deaminating; pyruvate-forming)

Comments: A pyridoxal-phosphate protein. The enzyme also slowly catalyses pyruvate formation from D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9059-31-8

References:

1. Kumagai, H., Yamada, H., Matsui, H., Ohkishi, H. and Ogata, K. Tyrosine phenol lyase. I. Purification, crystallization, and properties. J. Biol. Chem. 245 (1970) 1767-1772. [PMID: 4908868]

2. Kumagai, H., Yamada, H., Matsui, H., Ohkishi, H. and Ogata, K. Tyrosine phenol lyase. II. Cofactor requirements. J. Biol. Chem. 245 (1970) 1773-1777. [PMID: 4908869]

[EC 4.1.99.2 created 1972]


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