IUBMB Enzyme Nomenclature

EC 4.2.1.106

Accepted name: bile-acid 7α-dehydratase

Reaction: 7α,12α-dihydroxy-3-oxochol-4-enoate = 12α-hydroxy-3-oxochola-4,6-dienoate + H2O

For diagram click here.

Other name(s): 7α,12α-dihydroxy-3-oxochol-4-enoate hydro-lyase

Systematic name: 7α,12α-dihydroxy-3-oxochol-4-enoate hydro-lyase (12α-hydroxy-3-oxochola-4,6-dienoate-forming)

Comments: The enzyme from Eubacterium sp. strain VPI 12708 can also use 7α-hydroxy-3-oxochol-4-enoate as a substrate but not 7α,12α-dihydroxy-3-oxochol-5β-anoate, 3α,7α,12α-trihydroxychol-5β-anoate or 7β-hydroxy-3-oxochol-4-enoate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Dawson, J.A., Mallonee, D.H., Björkhem, I. and Hylemon, P.B. Expression and characterization of a C24 bile acid 7α-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli. J. Lipid Res. 37 (1996) 1258-1267. [PMID: 8808760]

[EC 4.2.1.106 created 2005]


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