IUBMB Enzyme Nomenclature


Accepted name: dammarenediol II synthase

Reaction: dammarenediol II = (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O

For diagram of reaction click here.

Other name(s): dammarenediol synthase; 2,3-oxidosqualene (20S)-dammarenediol cyclase; DDS; (S)-squalene-2,3-epoxide hydro-lyase (dammarenediol-II forming)

Systematic name: (3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (dammarenediol-II forming)

Comments: The reaction occurs in the reverse direction.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Tansakul, P., Shibuya, M., Kushiro, T. and Ebizuka, Y. Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng. FEBS Lett. 580 (2006) 5143-5149. [PMID: 16962103]

2. Han, J.Y., Kwon, Y.S., Yang, D.C., Jung, Y.R. and Choi, Y.E. Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng. Plant Cell Physiol. 47 (2006) 1653-1662. [PMID: 17088293]

[EC created 2011]

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