IUBMB Enzyme Nomenclature

EC 4.2.1.130

Accepted name: D-lactate dehydratase

Reaction: (R)-lactate = methylglyoxal + H2O

Glossary: methylglyoxal = 2-oxopropanal

Other name(s): glyoxylase III

Systematic name: (R)-lactate hydro-lyase

Comments: The enzyme converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:

References:

1. Misra, K., Banerjee, A.B., Ray, S. and Ray, M. Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione. Biochem. J. 305 ( Pt 3) (1995) 999-1003. [PMID: 7848303]

2. Subedi, K.P., Choi, D., Kim, I., Min, B. and Park, C. Hsp31 of Escherichia coli K-12 is glyoxalase III. Mol. Microbiol. 81 (2011) 926-936. [PMID: 21696459]

[EC 4.2.1.130 created 2011]


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