IUBMB Enzyme Nomenclature


Accepted name: 5,6,7,8-tetrahydromethanopterin hydro-lyase

Reaction: 5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O

Other name(s): formaldehyde-activating enzyme

Systematic name: 5,6,7,8-tetrahydromethanopterin hydro-lyase (formaldehyde-adding, tetrahydromethanopterin-forming)

Comments: Found in methylotrophic bacteria and methanogenic archaea.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Vorholt, J.A., Marx, C.J., Lidstrom, M.E. and Thauer, R.K. Novel formaldehyde-activating enzyme in Methylobacterium extorquens AM1 required for growth on methanol. J. Bacteriol. 182 (2000) 6645-6650. [PMID: 11073907]

2. Acharya, P., Goenrich, M., Hagemeier, C.H., Demmer, U., Vorholt, J.A., Thauer, R.K. and Ermler, U. How an enzyme binds the C1 carrier tetrahydromethanopterin. Structure of the tetrahydromethanopterin-dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1. J. Biol. Chem. 280 (2005) 13712-13719. [PMID: 15632161]

[EC created 2014]

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