IUBMB Enzyme Nomenclature

EC 4.2.1.17

Accepted name: enoyl-CoA hydratase

Reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O

For diagram of reaction click here.

Other name(s): enoyl hydrase; unsaturated acyl-CoA hydratase; β-hydroxyacyl-CoA dehydrase; β-hydroxyacid dehydrase; acyl coenzyme A hydrase; crotonase; crotonyl hydrase; 2-octenoyl coenzyme A hydrase; enoyl coenzyme A hydratase; 2-enoyl-CoA hydratase; short-chain enoyl-CoA hydratase; ECH; trans-2-enoyl-CoA hydratase; short-chain enoyl-CoA hydratase; enoyl coenzyme A hydrase (D); enoyl coenzyme A hydrase (L); short chain enoyl coenzyme A hydratase; D-3-hydroxyacyl-CoA dehydratase

Systematic name: (3S)-3-hydroxyacyl-CoA hydro-lyase

Comments: Acts in the reverse direction. With cis-compounds, yields (3R)-3-hydroxyacyl-CoA. cf. EC 4.2.1.74 long-chain-enoyl-CoA hydratase.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 9027-13-8

References:

1. Moskowitz, G.J. and Merrick, J.M. Metabolism of poly-β-hydroxybutyrate. II. Enzymatic synthesis of D-(–)-β-hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum. Biochemistry 8 (1969) 2748-2755. [PMID: 5808333]

2. Stern, J.R. Thioltranscrotylase and β-hydroxybutyryl CoA racemase activities of crystalline crotonase. Biochim. Biophys. Acta 26 (1957) 641-643.

[EC 4.2.1.17 created 1961]


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