Reaction: prephenate = phenylpyruvate + H2O + CO2
For diagram click here.
Other name(s): prephenate hydro-lyase (decarboxylating)
Systematic name: prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)
Comments: This enzyme in the enteric bacteria also possesses chorismate mutase (EC 18.104.22.168) activity, and converts chorismate into prephenate.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9044-88-6
1. Cerutti, P. and Guroff, G. Enzymatic formation of phenylpyruvic acid in Pseudomonas sp. (ATCC 11299A) and its regulation. J. Biol. Chem. 240 (1965) 3034-3048. [PMID: 14342329]
2. Cotton, R.G.H. and Gibson, F. The biosynthesis of phenylalanine and tyrosine; enzymes converting chorismic acid into prephenic acid and their relationships to prephenate dehydratase and prephenate dehydrogenase. Biochim. Biophys. Acta 100 (1965) 76-88.
3. Schmidt, J.C. and Zalkin, H. Chorismate mutase-prephenate dehydratase. Partial purification and properties of the enzyme from Salmonella typhimurium. Biochemistry 8 (1969) 174-181.