Reaction: (1) a (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = a trans-dec-2-enoyl-[acyl-carrier protein] + H2O
(2) a (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = a cis-dec-3-enoyl-[acyl-carrier protein] + H2O
Other name(s): D-3-hydroxydecanoyl-[acyl-carrier protein] dehydratase; 3-hydroxydecanoyl-acyl carrier protein dehydrase; 3-hydroxydecanoyl-acyl carrier protein dehydratase; β-hydroxydecanoyl thioester dehydrase; β-hydroxydecanoate dehydrase; β-hydroxydecanoyl thiol ester dehydrase; FabA; β-hydroxyacyl-acyl carrier protein dehydratase; HDDase; β-hydroxyacyl-ACP dehydrase
Systematic name: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] hydro-lyase
Comments: Specific for C10 chain length.
Links to other databases: BRENDA, EXPASY, KEGG, PDB, CAS registry number: 9030-79-9
References:
1. Kass, L.R., Brock, D.J. and Bloch, K. β-Hydroxydecanoyl thioester dehydrase. I. Purification and properties. J. Biol. Chem. 242 (1967) 4418-4431. [PMID: 4863739]
2. Brock, D.J.H., Kass, L.R. and Bloch, K. β-Hydroxydecanoyl thioester dehydrase. II. Mode of action. J. Biol. Chem. 242 (1967) 4432-4440. [PMID: 4863740]
3. Sharma, A., Henderson, B.S., Schwab, J.M. and Smith, J.L. Crystallization and preliminary X-ray analysis of β-hydroxydecanoyl thiol ester dehydrase from Escherichia coli. J. Biol. Chem. 265 (1990) 5110-5112. [PMID: 2180957]
4. Magnuson, K., Jackowski, S., Rock, C.O. and Cronan, J.E., Jr. Regulation of fatty acid biosynthesis in Escherichia coli. Microbiol. Rev. 57 (1993) 522-542. [PMID: 8246839]
5. Bloch, K. Enzymatic synthesis of monounsaturated fatty acids. Acc. Chem. Res. 2 (1969) 193-202.
6. Wang, H. and Cronan, J.E. Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues. J. Biol. Chem. 279 (2004) 34489-34495. [PMID: 15194690]
7. Cronan, J.E., Jr. and Rock, C.O. Biosynthesis of membrane lipids. In: Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd edn, vol. 1, ASM Press, Washington, DC, 1996, pp. 612-636.