Reaction: uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O
Other name(s): pseudouridylic acid synthetase; pseudouridine monophosphate synthetase; 5-ribosyluracil 5-phosphate synthetase; pseudouridylate synthetase; ψUMP synthetase; uracil hydro-lyase (adding D-ribose 5-phosphate)
Systematic name: uracil hydro-lyase (adding D-ribose 5'-phosphate; pseudouridine-5′-phosphate-forming)
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9023-35-2
References:
1. Heinrikson, R.L. and Goldwasser, E. Studies on the biosynthesis of 5-ribosyluracil 5'-monophosphate in Tetrahymena pyriformis. J. Biol. Chem. 239 (1964) 1177-1187. [PMID: 14165924]
2. Matsushita, T. and Davis, F.F. Studies on pseudouridylic acid synthetase from various sources. Biochim. Biophys. Acta 238 (1971) 165-173. [PMID: 4936431]
3. Rensen, J.F., Matsushita, T., Chirikjian, J.G. and Davis, F.F. Enzymatic synthesis of deoxypseudouridylic acid and a study of certain of its properties. Biochim. Biophys. Acta 281 (1972) 481-487. [PMID: 4569284]
4. Suzuki, T. and Hochater, R.M. On the biosynthesis of pseudouridine and of pseudouridylic acid in Agrobacterium tumefaciens. Can. J. Biochem. 44 (1966) 259-272. [PMID: 5942965]