IUBMB Enzyme Nomenclature

EC 4.2.1.74

Accepted name: long-chain-enoyl-CoA hydratase

Reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O

Glossary: a long-chain acyl-CoA = an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms.

Other name(s): long-chain enoyl coenzyme A hydratase

Systematic name: long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase

Comments: Acts in the reverse direction. The best substrate is oct-3-enoyl-CoA. Unlike EC 4.2.1.17 enoyl-CoA hydratase, it does not act on crotonoyl-CoA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 62009-81-8

References:

1. Fong, J.C. and Schulz, H. Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues. J. Biol. Chem. 252 (1977) 542-547. [PMID: 833142]

2. Schulz, H. Long chain enoyl coenzyme A hydratase from pig heart. J. Biol. Chem. 249 (1974) 2704-2709. [PMID: 4828315]

[EC 4.2.1.74 created 1981]


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