IUBMB Enzyme Nomenclature

EC 4.2.1.84

Accepted name: nitrile hydratase

Reaction: An aliphatic amide = a nitrile + H2O

Other name(s): nitrilase; 3-cyanopyridine hydratase; NHase; L-NHase; H-NHase; acrylonitrile hydratase; aliphatic nitrile hydratase; nitrile hydro-lyase

Systematic name: aliphatic-amide hydro-lyase (nitrile-forming)

Comments: Acts on short-chain aliphatic nitriles, converting them into the corresponding acid amides. Does not act on these amides or on aromatic nitriles. cf. EC 3.5.5.1 nitrilase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 82391-37-5

References:

1. Asano, Y., Fujishiro, K., Tani, Y. and Yamada, H. Microbial degradation of nitrile compounds. 5. Aliphatic nitrile hydratase from Arthrobacter sp J-1. Purification and characterization. Agric. Biol. Chem. 46 (1982) 1165-1174.

[EC 4.2.1.84 created 1989]


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