Reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH3
Glossary: octopamine = 1-(4-hydroxyphenyl)-2-aminoethanol
Other name(s): octopamine hydrolyase; octopamine hydro-lyase (deaminating)
Systematic name: 1-(4-hydroxyphenyl)-2-aminoethanol hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]
Comments: The enzyme-catalysed reaction is believed to be dehydration to an enamine, which is spontaneously hydrolysed to an aldehyde and ammonia.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 109456-55-5
1. Cuskey, S.M., Peccoraro, V. and Olsen, R.H. Initial catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO: pathway description, mapping of mutations, and cloning of essential genes. J. Bacteriol. 169 (1987) 2398-2404. [PMID: 3034855]