Reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O
For diagram of reaction click here.
Other name(s): acetohydroxyacid dehydratase; α,β-dihydroxyacid dehydratase; 2,3-dihydroxyisovalerate dehydratase; α,β-dihydroxyisovalerate dehydratase; dihydroxy acid dehydrase; DHAD; 2,3-dihydroxy-acid hydro-lyase; 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)
Systematic name: 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming)
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9024-32-2
1. Kanamori, M. and Wixom, R.L. Studies in valine biosynthesis. V. Characteristics of the purified dihydroxyacid dehydratase from spinach leaves. J. Biol. Chem. 238 (1963) 998-1005.
2. Myers, J.W. Dihydroxy acid dehydrase: an enzyme involved in the biosynthesis of isoleucine and valine. J. Biol. Chem. 236 (1961) 1414-1418. [PMID: 13727223]