IUBMB Enzyme Nomenclature


Accepted name: scytalone dehydratase

Reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O

Other name(s): scytalone 7,8-hydro-lyase

Systematic name: scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)

Comments: Involved, with EC tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 118901-79-4


1. Butler, M.J., Lazarovits, G., Higgins, V.J. and Lachance, M.-A. Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi. Exp. Mycol. 12 (1988) 367-376.

2. Tajima, S., Kubo, Y., Furusawa, I. and Shishiyama, J. Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus. Exp. Mycol. 13 (1989) 69.

3. Wheeler, M.H. and Greenblatt, G.A. The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease. Exp. Mycol. 12 (1988) 151-160.

[EC created 1992]

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