IUBMB Enzyme Nomenclature


Accepted name: 4a-hydroxytetrahydrobiopterin dehydratase

Reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O

For diagram click here.

Glossary: 4a-hydroxytetrahydrobiopterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin

Other name(s): 4α-hydroxy-tetrahydropterin dehydratase; pterin-4α-carbinolamine dehydratase; 4a-hydroxytetrahydrobiopterin hydro-lyase

Systematic name: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]

Comments: catalyses the dehydration of 4a-hydroxytetrahydrobiopterins

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 87683-70-3


1. Hauer, C.R., Rebrin, I., Thöny, B., Neuheiser, F., Curtius, H.C., Hunziker, P., Blau, N., Ghisla, S., Heizmann, C.W. Phenylalanine hydroxylase-stimulating protein: pterin-4α-carbinolamine dehydratase from rat and human liver. J. Biol. Chem. 268 (1993) 4828-4831. [PMID: 8444860]

[EC created 1999]

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