IUBMB Enzyme Nomenclature


Accepted name: 2-methylisoborneol synthase

Reaction: (E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate

For diagram of reaction click here and mechanism click here.

Other name(s): sco7700; 2-MIB cyclase; MIB synthase; MIBS

Systematic name: (E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming)

Comments: The product, 2-methylisoborneol, is a characteristc odiferous compound with a musty smell produced by soil microorganisms.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Wang, C.M. and Cane, D.E. Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor. J. Am. Chem. Soc. 130 (2008) 8908-8909. [PMID: 18563898]

2. Komatsu, M., Tsuda, M., Omura, S., Oikawa, H. and Ikeda, H. Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol. Proc. Natl. Acad. Sci. USA 105 (2008) 7422-7427. [PMID: 18492804]

3. Giglio, S., Chou, W.K., Ikeda, H., Cane, D.E. and Monis, P.T. Biosynthesis of 2-methylisoborneol in cyanobacteria. Environ. Sci. Technol. 45 (2011) 992-998. [PMID: 21174459]

[EC created 2012]

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