IUBMB Enzyme Nomenclature


Accepted name: α-copaene synthase

Reaction: (2E,6E)-farnesyl diphosphate = (–)-α-copaene + diphosphate

For diagram of reaction click here.

Glossary: (–)-α-copaene = (1R,2S,6S,7S,8S)-1,3-dimethyl-8-(propan-2-yl)tricyclo[,7]dec-3-ene
For diagram of the structures of α-copaene and β-copaene, click here

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, α-copaene-forming)

Comments: Isolated from Helianthus annuus (sunflower). The enzyme also produces β-caryophyllene, δ-cadinene and traces of other sesquiterpenoids. See EC (+)-δ-cadinene synthase, EC (–)-β-caryophyllene synthase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Gopfert, J.C., Macnevin, G., Ro, D.K. and Spring, O. Identification, functional characterization and developmental regulation of sesquiterpene synthases from sunflower capitate glandular trichomes. BMC Plant Biol. 9 (2009) 86. [PMID: 19580670]

2. Xie, X., Kirby, J. and Keasling, J.D. Functional characterization of four sesquiterpene synthases from Ricinus communis (castor bean). Phytochemistry 78 (2012) 20-28. [PMID: 22459969]

[EC created 2012]

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