IUBMB Enzyme Nomenclature


Accepted name: methylglyoxal synthase

Reaction: glycerone phosphate = methylglyoxal + phosphate

Glossary: glycerone phosphate = dihydroxyacetone phosphate = 3-hydroxy-2-oxopropyl phosphate
methylglyoxal = 2-oxopropanal

Other name(s): methylglyoxal synthetase; glycerone-phosphate phospho-lyase

Systematic name: glycerone-phosphate phosphate-lyase (methylglyoxal-forming)

Comments: Does not act on D-glyceraldehyde 3-phosphate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37279-01-9


1. Cooper, R.A. and Anderson, A. The formation and catabolism of methylglyoxal during glycolysis in Escherichia coli. FEBS Lett. 11 (1970) 273-276. [PMID: 11945504]

2. Hopper, D.J. and Cooper, R.A. The regulation of Escherichia coli methylglyoxal synthase; a new control site in glycolysis? FEBS Lett. 13 (1971) 213-216. [PMID: 11945670]

3. Ray, S. and Ray, M. Isolation of methylglyoxal synthase from goat liver. J. Biol. Chem. 256 (1981) 6230-6233. [PMID: 7240200]

[EC created 1972 as EC, transferred 2000 to EC]

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