IUBMB Enzyme Nomenclature


Accepted name: epi-isozizaene synthase

Reaction: (2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate

For diagram of reaction click here and mechanism click here.

Glossary: for epi-isozizaene click here.

Other name(s): SCO5222 protein

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming]

Comments: Requires Mg2+ for activity. The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration [1]. In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC, epi-isozizaene 5-monooxygenase, to produce the sesquiterpene antibiotic albaflavenone [2].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Lin, X., Hopson, R. and Cane, D.E. Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase. J. Am. Chem. Soc. 128 (2006) 6022-6023. [PMID: 16669656]

2. Zhao, B., Lin, X., Lei, L., Lamb, D.C., Kelly, S.L., Waterman, M.R. and Cane, D.E. Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). J. Biol. Chem. 283 (2008) 8183-8189. [PMID: 18234666]

[EC created 2008]

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