IUBMB Enzyme Nomenclature


Accepted name: epi-cedrol synthase

Reaction: (2E,6E)-farnesyl diphosphate + H2O = 8-epi-cedrol + diphosphate

For diagram of reaction click here and mechanism click here.

Other name(s): 8-epicedrol synthase; epicedrol synthase

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming)

Comments: The enzyme is activated by Mg2+ [2]. Similar to many other plant terpenoid synthases, this enzyme produces many products from a single substrate. The predominant product is the cyclic sesquiterpenoid alcohol, 8-epi-cedrol, with minor products including cedrol and the olefins α-cedrene, β-cedrene, (E)-β-farnesene and (E)-α-bisabolene [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Mercke, P., Crock, J., Croteau, R. and Brodelius, P.E. Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L. Arch. Biochem. Biophys. 369 (1999) 213-222. [PMID: 10486140]

2. Hua, L. and Matsuda, S.P. The molecular cloning of 8-epicedrol synthase from Artemisia annua. Arch. Biochem. Biophys. 369 (1999) 208-212. [PMID: 10486139]

[EC created 2009]

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