IUBMB Enzyme Nomenclature


Accepted name: γ-humulene synthase

Reaction: (2E,6E)-farnesyl diphosphate = γ-humulene + diphosphate

For diagram of reaction click here.

Other name(s): humulene cyclase

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (γ-humulene-forming)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Steele, C.L., Crock, J., Bohlmann, J. and Croteau, R. Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of δ-selinene synthase and γ-humulene synthase. J. Biol. Chem. 273 (1998) 2078-2089. [PMID: 9442047]

2. Little, D.B. and Croteau, R.B. Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases δ-selinene synthase and γ-humulene synthase. Arch. Biochem. Biophys. 402 (2002) 120-135. [PMID: 12051690]

[EC created 2011]

Return to EC 4.2.3 home page
Return to EC 4.2 home page
Return to EC 4 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page