Reaction: (2E,6E)-farnesyl diphosphate = pentalenene + diphosphate
For reaction pathway click here.
Other name(s): pentalenene synthetase; 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)
Systematic name: (2E,6E)-farnesyl diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)
Comments: The initial step in the reaction is probably a cyclization of farnesyl diphosphate to form humulene. The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics.
Links to other databases: BRENDA, EXPASY, KEGG, PDB, CAS registry number: 90597-46-9
References:
1. Cane, D.E. Cell-free studies of monoterpene and sesquiterpene biosynthesis. Biochem. Soc. Trans. 11 (1983) 510-515. [PMID: 6642060]
2. Cane, D.E. and Tillman, A.M. Pentalenene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate. J. Am. Chem. Soc. 105 (1983) 122-124.
3. Cane, D.E., Sohng, J.K., Lamberson, C.R., Rudnicki, S.M., Wu, Z., Lloyd, M.D., Oliver, J.S. and Hubbard, B.R. Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319. Biochemistry 33 (1994) 5846-5857. [PMID: 8180213]