IUBMB Enzyme Nomenclature


Accepted name: (+)-β-caryophyllene synthase

Reaction: (2E,6E)-farnesyl diphosphate = (+)-β-caryophyllene + diphosphate

For diagram of reaction click here.

Other name(s): GcoA

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-β-caryophyllene-forming]

Comments: A multifunctional enzyme which also converts the (+)-β-caryophyllene to (+)-caryolan-1-ol (see EC, (+)-caryolan-1-ol synthase). cf. EC (–)-β-caryophyllene synthase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Nakano, C., Horinouchi, S. and Ohnishi, Y. Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus. J. Biol. Chem. 286 (2011) 27980-27987. [PMID: 21693706]

[EC created 2011]

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