Reaction: (2E,6E)-farnesyl diphosphate = (+)-β-caryophyllene + diphosphate
For diagram of reaction click here.
Other name(s): GcoA
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-β-caryophyllene-forming]
Comments: A multifunctional enzyme which also converts the (+)-β-caryophyllene to (+)-caryolan-1-ol (see EC 22.214.171.124, (+)-caryolan-1-ol synthase). cf. EC 126.96.36.199 ()-β-caryophyllene synthase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Nakano, C., Horinouchi, S. and Ohnishi, Y. Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus. J. Biol. Chem. 286 (2011) 27980-27987. [PMID: 21693706]