Reaction: (2E,6E)-farnesyl diphosphate + H2O = cubebol + diphosphate
For diagram of reaction click here.
Other name(s): Cop4
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, cubebol-forming)
Comments: Requires Mg2+. The enzyme gives 28% cubebol, 29% ()-germacrene D, 10% (+)-δ-cadinene and traces of several other sesquiterpenoids. See also EC 18.104.22.168 ()-germacrene D synthase and EC 22.214.171.124 (+)-δ-cadinene synthase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Lopez-Gallego, F., Agger, S.A., Abate-Pella, D., Distefano, M.D. and Schmidt-Dannert, C. Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers. Chembiochem. 11 (2010) 1093-1106. [PMID: 20419721]