Reaction: L-serine = pyruvate + NH3
Other name(s): serine deaminase; L-hydroxyaminoacid dehydratase; L-serine deaminase; L-serine dehydratase; L-serine hydro-lyase (deaminating)
Systematic name: L-serine ammonia-lyase (pyruvate-forming)
Comments: A pyridoxal-phosphate protein. This reaction is also carried out by EC 220.127.116.11 threonine ammonia-lyase, from a number of sources. The reaction catalysed probably involves initial elimination of water (hence the enzyme's original classification as EC 18.104.22.168, L-serine dehydratase), followed by isomerization and hydrolysis of the product with C-N bond breakage.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9014-27-1
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2. Simon, D., Hoshino, J. and Kröger, H. L-Serine dehydratase from rat liver. Purification and some properties. Biochim. Biophys. Acta 321 (1973) 361-368. [PMID: 4750769]
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