Reaction: D-serine = pyruvate + NH3
Other name(s): D-hydroxyaminoacid dehydratase; D-serine dehydrase; D-hydroxy amino acid dehydratase; D-serine hydrolase; D-serine dehydratase (deaminating); D-serine deaminase; D-serine hydro-lyase (deaminating); D-serine ammonia-lyase
Systematic name: D-serine ammonia-lyase (pyruvate-forming)
Comments: A pyridoxal-phosphate protein. Also acts, slowly, on D-threonine. The reaction catalysed probably involves initial elimination of water (hence the enzyme's original classification as EC 4.2.1.14, D-serine dehydratase), followed by isomerization and hydrolysis of the product with C-N bond breakage.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 9015-88-7
References:
1. Dupourque, D., Newton, W.A. and Snell, E.E. Purification and properties of D-serine dehydrase from Escherichia coli. J. Biol. Chem. 241 (1966) 1233-1238. [PMID: 5327100]
2. Metzler, D.E. and Snell, E.E. Deamination of serine. II. D-Serine dehydrase, a vitamin B6 enzyme from Escherichia coli. J. Biol. Chem. 198 (1952) 363-373. [PMID: 12999751]