IUBMB Enzyme Nomenclature

EC 4.3.2.3

Accepted name: ureidoglycolate lyase

Reaction: (S)-ureidoglycolate = glyoxylate + urea

For diagram of reaction click here.

Other name(s): ureidoglycolatase (ambiguous); ureidoglycolase (ambiguous); ureidoglycolate hydrolase (misleading); (S)-ureidoglycolate urea-lyase

Systematic name: (S)-ureidoglycolate urea-lyase (glyoxylate-forming)

Comments: This microbial enzyme is involved in the degradation of ureidoglycolate, an intermediate of purine degradation. Not to be confused with EC 3.5.1.116, ureidoglycolate amidohydrolase, which releases ammonia rather than urea.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, CAS registry number: 9014-57-7

References:

1. Trijbels, F. and Vogels, G.D. Allantoate and ureidoglycolate degradation by Pseudomonas aeruginosa. Biochim. Biophys. Acta 132 (1967) 115-126. [PMID: 6030341]

2. Werner, A.K., Romeis, T. and Witte, C.P. Ureide catabolism in Arabidopsis thaliana and Escherichia coli. Nat. Chem. Biol. 6 (2010) 19-21. [PMID: 19935661]

[EC 4.3.2.3 created 1972, modified 2014]


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