IUBMB Enzyme Nomenclature

EC 4.3.2.6

Accepted name: γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase

Reaction: γ-L-glutamyl-butirosin B = butirosin B + 5-oxoproline

Glossary: γ-L-glutamyl-butirosin B = (1R,2R,3S,4R,6S)-6-amino-4-{[(2R)-4-(L-γ-glutamylamino)-2-hydroxybutanoyl]amino}-3-hydroxy-2-(α-D-ribofuranosyloxy)cyclohexyl

Other name(s): btrG (gene name)

Systematic name: γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase (5-oxoproline producing)

Comments: The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the α-amine of the terminal γ-L-glutamate of the side chain, releasing it as the cyclic 5-oxoproline.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Llewellyn, N.M., Li, Y. and Spencer, J.B. Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain. Chem. Biol. 14 (2007) 379-386. [PMID: 17462573]

[EC 4.3.2.6 created 2012]


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