Reaction: RS-CH2-CH(NH3+)COO- + H2O = RSH + NH3 + pyruvate
Other name(s): cysteine conjugate β-lyase; glutamine transaminase K/cysteine conjugate β-lyase; L-cysteine-S-conjugate thiol-lyase (deaminating)
Systematic name: L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)
Comments: A pyridoxal-phosphate protein. In the reaction, RH may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitrobenzene.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 68652-57-3
1. Tateishi, M., Suzuki, S. and Shimizu, H. Cysteine conjugate β-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs. J. Biol. Chem. 253 (1978) 8854-8859. [PMID: 721818]