IUBMB Enzyme Nomenclature


Accepted name: S-(hydroxymethyl)glutathione synthase

Reaction: S-(hydroxymethyl)glutathione = glutathione + formaldehyde

Other name(s): glutathione-dependent formaldehyde-activating enzyme; Gfa; S-(hydroxymethyl)glutathione formaldehyde-lyase

Systematic name: S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)

Comments: The enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 425642-27-9


1. Goenrich, M., Bartoschek, S., Hagemeier, C.H., Griesinger, C. and Vorholt, J.A. A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy. J. Biol. Chem. 277 (2002) 3069-3072. [PMID: 11741920]

[EC created 2005 (EC created 1961, modified 1982, modified 2002, part transferred 2005 to EC]

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