Reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal
Glossary: methylglyoxal = 2-oxopropanal
Other name(s): methylglyoxalase; aldoketomutase; ketone-aldehyde mutase; glyoxylase I; (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing)
Systematic name: (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)
Comments: Also acts on 3-phosphoglycerol-glutathione.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9033-12-9
1. Ekwall, K. and Mannervik, B. The stereochemical configuration of the lactoyl group of S-lactoylglutathionine formed by the action of glyoxalase I from porcine erythrocytes and yeast. Biochim. Biophys. Acta 297 (1973) 297-299. [PMID: 4574550]
2. Racker, E. The mechanism of action of glyoxalase. J. Biol. Chem. 190 (1951) 685-696. [PMID: 14841219]